Postdoc (m/f/d) – Translational Cancer Research | Gastroenterology

The Department of Internal Medicine II at TUM Klinikum rechts der Isar is recruiting a highly motivated Postdoctoral Researcher to join our newly established Max Eder Research Group.

Our research aims to decipher the molecular mechanisms of tumor evolution, cellular plasticity, and therapy resistance in gastric and gastroesophageal adenocarcinoma (GEAC).

By integrating longitudinal patient samples from prospective clinical trials with cutting-edge multi-omics technologies and functional model systems, our group is committed to understanding the biological mechanisms underlying treatment resistance in upper gastrointestinal cancers and translating these discoveries into novel therapeutic strategies.

The position offers the unique opportunity to work at the interface of clinical oncology, cancer genomics, computational biology, and functional cancer research within an outstanding translational research environment.

You will investigate the molecular mechanisms of tumor evolution, cellular plasticity, and therapy resistance in GEAC through the integration of longitudinal multi-omics datasets from prospective clinical trial samples.

Your research will focus on computational analysis and interpretation of large-scale molecular datasets, including:

Analysis and integration of single-cell and spatial transcriptomic datasets to characterize tumor evolution and treatment response

Inference of tissue-specific gene expression and tumor activity from plasma cell-free DNA fragmentation patterns

Development of computational approaches for the integration of genomic, transcriptomic, epigenomic and immune profiling data

Multi-omics integration to reconstruct tumor evolutionary trajectories and characterize cellular plasticity during treatment

Development and implementation of bioinformatic pipelines for high-dimensional sequencing datasets

Close collaboration with clinicians, biologists, computational biologists and international collaborators

Presentation of research at international conferences and publication in high-impact scientific journals

We are seeking an ambitious computational scientist with a strong interest in translational cancer research and multi-omics data analysis.

Required qualifications

PhD in Bioinformatics, Computational Biology, Computer Science, Data Science, Biomedical Sciences, Cancer Genomics or a related quantitative discipline

Strong experience in the analysis of next-generation sequencing data (e.g. transcriptomic and/or genomic datasets)

Excellent programming skills in R and/or Python

Experience working in Linux/Unix environments and using reproducible computational workflows

Ability to independently design and drive scientific projects

Excellent communication skills and proficiency in English

Preferred qualifications

Experience in one or more of the following areas is highly desirable:

Cell-free DNA sequencing and fragmentation analysis (highly desirable)

Single-cell RNA sequencing analysis and/or Spatial transcriptomics

Multi-omics integration

Machine learning or statistical modelling of biological datasets

Cancer genomics and tumor evolution

A postdoctoral position within a newly established and rapidly growing Max Eder Research Group funded by the German Cancer Aid

An outstanding translational research environment embedded within TUM Klinikum rechts der Isar, one of Europe’s leading academic medical centers

Close collaboration with internationally renowned research groups at the Institute of Cancer Research (ICR), Sutton, UK, and Chalmers University of Technology, Gothenburg, Sweden, including opportunities for scientific exchange and short-term research stays at both partner institutions.

Direct integration with prospective clinical trials and longitudinal patient cohorts

Close collaboration with physicians, computational biologists and internationally recognized research partners

Strong mentorship and excellent opportunities for scientific independence and career development

Support for national and international conference attendance

Competitive salary according to TV-L

EGYM Wellpass, corporate benefits, company pension scheme (VBL), cafeteria, sports and cultural offers

Modern workplace in the heart of Munich with excellent public transport connections

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given

preference.

Interview-related costs can, unfortunately, not be reimbursed.