PhD Researcher (m/f/d) – Cannabidiol in radiotherapy in glioblastoma

As part of a three-year PhD project, the successful candidate will investigate the protective and antitumoral effects of cannabidiol (CBD) in combination with radiotherapy in glioblastoma.

The project focuses on how CBD affects tumor radiosensitivity, the tumor microenvironment, and, in particular the function and integrity of healthy brain tissue.

You will work with established glioblastoma mouse models and clinically relevant irradiation protocols

A particular focus will be the functional characterization of the brain using electrophysiological approaches, including LTP recordings, extracellular field potential recordings and whole-cell patch-clamp, as well as live-cell and high-resolution imaging, including calcium imaging and optoacoustic imaging.

Complementary morphological, molecular and immunological analyses will be performed to link functional alterations to their structural and molecular mechanisms.

A central objective is the quantitative integration of electrophysiological and imaging data to elucidate the mechanisms underlying radiation-induced neuronal damage and potential CBD-mediated neuroprotection.

We are looking for a highly motivated candidate with a Master’s degree in neuroscience, biology, biophysics, physiology, pharmacology or a related discipline, with a strong interest in interdisciplinary experimental research.

practical experience in electrophysiology, especially patch-clamp or extracellular recordings

experience with live-cell, calcium or confocal imaging and quantitative image analysis

an interest in neuronal plasticity and functional alterations of the brain

willingness to learn and apply new techniques, including optoacoustic imaging and experimental animal procedures.

Experience in glioblastoma, cancer or radiation research is advantageous but not essential.

Most importantly, we are looking for experimental skills, scientific curiosity, independence and the ability to integrate electrophysiological, imaging and molecular findings into a coherent mechanistic framework

A three-year PhD project (60% part-time)

EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers, company bike

Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram

Company pension plan through the Federal and State Pension Institute (VBL)

Self-realization through a varied and technically demanding job with interdisciplinary cooperation between various departments of the TUM Klinikum

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference.

Interview-related costs can, unfortunately, not be reimbursed.